Brochure
| We want to take you higher. Your standards for catfish health and performance are about to reach new highs. Reach new highs with AQUAFLOR®(Florfenicol) | |
| • | High performance |
| • | High margin of safety |
| • | High palatability |
| • | High convenience |
Introducing AQUAFLOR for Channel Catfish Introducing AQUAFLOR for channel catfish — the first antibiotic licensed for US aquaculture in more than 20 years. It’s more than a new-generation, in-feed antibiotic. With early diagnostics and proactive management, AQUAFLOR will redefine your standards for stocking rates, fish survival and profitability. It’s safe and highly palatable, too. Contact your diagnostic lab, veterinarian or feed supplier today and say you want to bring your fish health program to a new high. The sky’s your limit from here.
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| • | Now approved for the control of mortality in catfish due to enteric septicemia (ESC) of catfish associated with Edwardsiella ictaluri — the top disease problem in catfish that costs farmers $13 million in losses each year(1) |
| • | New-generation, broad-spectrum antibiotic with unique molecular structure |
| • | Fast-acting for rapid decline in mortality rates(2) |
| • | Keeps fish healthy so they stay on feed for optimum survival, growth and returns(3) |
| • | Reduces mortality so you can reduce stocking rates, lower costs of production |
| • | Exclusive Veterinary Feed Directive status ensures correct usage |
Treating with AQUAFLOR results in significantly lower ESC mortality and infection rates. | |
| • | Challenged fingerlings treated with AQUAFLOR had a cumulative mortality rate of 0.8%, compared to 60% for challenged, untreated fish (p< 0.0001)(4) |
| • | Challenged fingerlings treated with AQUAFLOR showed an infection rate of only 1.7%, compared to 72.3% for challenged, untreated fish (p< 0.0001)(5) |
| • | No adverse reactions to AQUAFLOR(6) |
| • | Excellent feed consumption with AQUAFLOR(7) |
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High Margin of Safety | |
| • | Excellent safety profile for fish, human food, environment |
| • | Well tolerated by fingerlings and food fish — with no performance setback |
| • | Developed specifically for use in fish and food animal species — market your product with added confidence |
Safety study Trials were conducted to evaluate the safety of AQUAFLOR when used… | |
| • | Up to 10 times the recommended dose rate over the prescribed treatment period of 10 days |
| • | Up to 5 times the recommended dose rate over 20 days or twice the prescribed treatment period |
Results | |
| • | 100% survival rate for fish treated with AQUAFLOR |
| • | No negative effect on feed consumption or growth |
| • | No significant lesions from treatments |
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| High Palatability | |
| • | Fish consume feed with AQUAFLOR — palatability comparable to unmedicated feed |
| • | Studies show fish stay on feed throughout treatment period |
| • | Minimize wasted feed, maximize antibiotic intake |
| • | Uniform granulation for optimum distribution in feed and more precise dosage delivery |
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High Convenience | |
| • | Used in floating feed — easy to monitor feed and antibiotic intake |
| • | Excellent stability in extruded feed |
| • | Can be fed from fingerling to food fish |
| • | Flexible marketing with 12-day withdrawal time |
| __________________________________________________________ NDC 0061-135501 2.0 kg (4.4 lb) AQUAFLOR® Type A Medicated Article (florfenicol), An Antibiotic 2.0 kg (4.4 lb) For Use in Catfish Feeds Only CAUTION: Federal law limits this drug to use under the professional supervision of a licensed veterinarian. Animal feed bearing or containing this veterinary feed directive drug shall be fed to animals only by or upon a lawful veterinary feed directive (VFD) issued by a licensed veterinarian in the course of the veterinarian’s professional practice. Active Drug Ingredient: Florfenicol 500 g per kg (227.27 g per lb). Inert Ingredients: Lactose and Povidone. Description: Each kg of AQUAFLOR Type A Medicated Article contains 500 grams (1.1 lb) of the antibiotic florfenicol in a palatable base. Activity: In vitro and in vivo investigations in catfish have established florfenicol’s activity against Edwardsiella ictaluri (Table 1). | |
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| Indication: For the control of mortality in catfish due to enteric septicemia of catfish associated with Edwardsiella ictaluri. Caution: The effects of florfenicol on reproductive performance have not been determined. A dose-related decrease in hematopoietic/lymphopoietic tissue may occur. The time required for the hematopoietic/lymphopoietic tissues to regenerate was not evaluated. IMPORTANT: Must be thoroughly mixed in feeds before use. Mixing Instructions: For making AQUAFLOR Type C Medicated Feed for catfish: a) AQUAFLOR is added to other feed ingredients in the mixer prior to extrusion, b) the medicated feed is mixed thoroughly to insure homogeneity, c) the mixture is extruded and pellets are dried, d) the pellets are dry-mixed/coated with a predetermined amount of fish or vegetable oil, and e) at the completion of mixing, the product is transferred to a storage tank for packaging or transport. | |
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Feeding Directions: Feed as the sole ration for 10 consecutive days. AQUAFLOR medicated feed should only be administered once disease associated with Edwardsiella ictaluri has been appropriately diagnosed. Feeding fish at a percent of biomass and corresponding florfenicol concentration included in the table above will provide a daily dose rate of 10 mg florfenicol per kg of fish. Caution: Feed containing AQUAFLOR (florfenicol) shall not be fed to catfish for more than 10 days. Following administration, fish should be reevaluated by a licensed veterinarian before reinitiating further course of therapy. The expiration date for VFD for AQUAFLOR (florfenicol) must not exceed 15 days from the date of issuance. VFD for AQUAFLOR (florfenicol) shall not be refilled. WARNING: Avoid inhalation, oral exposure, and direct contact with skin or eyes. Operators mixing and handling AQUAFLOR® should use protective clothing, gloves, goggles and NIOSH-approved dust mask. Wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. Not for human consumption. Keep out of reach of children. The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. For more information or to report adverse effects, call 1-800-224-5318. For customer service, call 1-800-521-5767. For a copy of the MSDS sheet, call 1-800-770-8878. STORAGE CONDITIONS: Store at 2-30°C (36-86°F).
References (3) Ibid. (4) Ibid. (5) Ibid. (6) Ibid. (7) Gaunt P, Endris RG, Khoo L, McGinnis A, Santucci T, Leard T, Jack S, Katz T, Radecki SV, Simmons R. 2003. Preliminary assessment of the tolerance and efficacy of florfenicol against Edwardsiella ictaluri administered in feed to channel catfish. Journal of Aquatic Animal Health. 15:239-247. (8) Ibid.
AQUAFLOR is a registered trademark of Schering-Plough Veterinary Corporation. | |